No, while both provide P100 particulate protection, they use different facepiece platforms. The 52P71 uses the 3M 5000 series facepiece, while the 6291 uses the 3M 6000 series. The 6000 series (6291) offers a more comfortable fit, easier bayonet-style filter changes, and lower breathing resistance. The 5000 series (52P71) is more affordable and suitable for occasional or light-duty use.